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Troponin assays are not merely much more sensitive but are much more precise than CK-MB assays. Expression of CK-MB just isn't exceptional to the heart.37 CK-MB is found in skeletal muscle plus the gastrointestinal tract as well as inside the uterus of Expecting Ladies.38 Additionally, in people with myopathies, the CK-MB information of skeletal muscle mass can enhance markedly to around fifty% of the full amount for each gram of tissue.
32 Even so, There exists massive variability from the sensitivity of assays, which is by no means reflected within the values documented for the various assays. The right Minimize-off worth for each assay is unique and can't be in contrast with almost every other.33,34 These dissimilarities are because of partially to the heterogeneity of the antibodies and matrix components of your assays.nine,35 Also they are due to truth that there are several fragments of troponin that circulate, along with the antibodies used in the varied assays detect these fragments in a different way.36
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74. Morrow DA, Cannon CP, Rifai N, et al. Means of insignificant elevations of troponins I and T to predict take advantage of an early invasive system in patients with unstable angina and non-ST elevation myocardial infarction: success from the randomized trial. JAMA
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